Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Entrez GeneID

Protein Accession#

Gene Name

ATP1B1

Gene Alias

ATP1B, MGC1798

Gene Description

ATPase, Na+/K+ transporting, beta 1 polypeptide

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq

Other Designations

Beta 1-subunit of Na(+),K(+)-ATPase|Na+/K+ -ATPase beta 1 subunit|Na, K-ATPase beta-1 polypeptide|Na,K-ATPase beta 1 subunit|OTTHUMP00000032537|OTTHUMP00000032538|adenosinetriphosphatase|sodium/potassium-dependent ATPase beta-1 subunit|sodium/potassium-tr