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Entrez GeneID

Protein Accession#

Gene Name

ATP6V0D1

Gene Alias

ATP6D, ATP6DV, P39, VATX, VMA6, VPATPD

Gene Description

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1

Omim ID

Gene Ontology

Gene Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq

Other Designations

ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D|ATPase, H+ transporting, lysosomal 38kD, V0 subunit d|ATPase, H+ transporting, lysosomal, V0 subunit d1|H(+)-transporting two-sector ATPase, subunit D|V-ATPase 40 KDa accessory protein|V-