PABPN1 recombinant monoclonal antibody, clone 6C3
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: 293 whole cell lysate; Lane 2: MCF-7 whole cell lysate; Lane 3: Raji whole cell lysate; Lane 4: HepG2 whole cell lysate.
Immunohistochemistry
Immunohistochemistry image of PABPN1 recombinant monoclonal antibody, clone 6C3 diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system.
Immunofluorescence
Immunofluorescence staining of Hela Cells with PABPN1 recombinant monoclonal antibody, clone 6C3 at 1:50, counter-stained with DAPI.
Flow Cytometry
Overlay histogram showing Hela cells stained with PABPN1 recombinant monoclonal antibody, clone 6C3 (red line) at 1:50.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human PABPN1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human PABPN1.
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
ELISA
Flow Cytometry (1:20-1:200)
Immunohistochemistry (1:50-1:200)
Immunofluorescence(1:20-1:200)
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: 293 whole cell lysate; Lane 2: MCF-7 whole cell lysate; Lane 3: Raji whole cell lysate; Lane 4: HepG2 whole cell lysate.Immunohistochemistry
Immunohistochemistry image of PABPN1 recombinant monoclonal antibody, clone 6C3 diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system.Immunofluorescence
Immunofluorescence staining of Hela Cells with PABPN1 recombinant monoclonal antibody, clone 6C3 at 1:50, counter-stained with DAPI.Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Overlay histogram showing Hela cells stained with PABPN1 recombinant monoclonal antibody, clone 6C3 (red line) at 1:50. -
Gene Info — PABPN1
Entrez GeneID
8106Protein Accession#
Q86U42Gene Name
PABPN1
Gene Alias
OPMD, PAB2, PABP2
Gene Description
poly(A) binding protein, nuclear 1
Gene Ontology
HyperlinkGene Summary
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails on the 3' ends of eukaryotic genes and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. An expansion of the trinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end of the coding region of this gene leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Multiple splice variants have been described but their full-length nature is not known. One splice variant includes introns 1 and 6 but no protein is formed. [provided by RefSeq
Other Designations
poly(A) binding protein 2|poly(A) binding protein II
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Interactome
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Disease
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