NR3C1 recombinant monoclonal antibody, clone 2D8
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human NR3C1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human NR3C1.
Reactivity
Human
Form
Liquid
Purification
Affinity-chromatography
Isotype
IgG
Recommend Usage
ELISA
Flow Cytometry (1:20-1:200)
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: 293 whole cell lysate; Lane 2: Hela whole cell lysate; Lane 3: HepG2 whole cell lysate; Lane 4: Jurkat whole cell lysate; Lane 5: A549 whole cell lysate; Lane 6: MCF-7 whole cell lysate; Lane 7: U87 whole cell lysate.Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Overlay histogram showing Jurkat cells stained with NR3C1 recombinant monoclonal antibody, clone 2D8 (red line) at 1:50. -
Gene Info — NR3C1
Entrez GeneID
2908Protein Accession#
P04150Gene Name
NR3C1
Gene Alias
GCCR, GCR, GR, GRL
Gene Description
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Omim ID
138040Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. [provided by RefSeq
Other Designations
nuclear receptor subfamily 3, group C, member 1
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