NR3C1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NR3C1.
Immunogen
A synthetic peptide corresponding to human NR3C1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to NR3C1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from Jurkat cells, treated with EGF (200 ng/mL, 15 mins), using NR3C1 polyclonal antibody (Cat # PAB18154).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using NR3C1 polyclonal antibody (Cat # PAB18154).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — NR3C1
Entrez GeneID
2908Protein Accession#
P04150Gene Name
NR3C1
Gene Alias
GCCR, GCR, GR, GRL
Gene Description
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Omim ID
138040Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. [provided by RefSeq
Other Designations
nuclear receptor subfamily 3, group C, member 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Characterization of transgenic Arabidopsis plants overexpressing GR-RBP4 under high salinity, dehydration, or cold stress.
Kwak KJ, Kim YO, Kang H.
Journal of Experimental Botany 2005 Nov; 56(421):3007.
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The Y chromosome gr/gr subdeletion is associated with male infertility.
Lynch M, Cram DS, Reilly A, O'Bryan MK, Baker HW, de Kretser DM, McLachlan RI.
Molecular Human Reproduction 2005 Jul; 11(7):507.
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High frequency of gr/gr chromosome Y deletions in consecutive oligospermic ICSI candidates.
de Llanos M, Ballesca JL, Gazquez C, Margarit E, Oliva R.
Human Reproduction (Oxford, England) 2005 Jan; 20(1):216.
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Characterization of transgenic Arabidopsis plants overexpressing GR-RBP4 under high salinity, dehydration, or cold stress.
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