INPP5D recombinant monoclonal antibody, clone 9G11
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: Raji whole cell lysate; Lane 2: K562 whole cell lysate.
Immunohistochemistry
Immunohistochemistry image of INPP5D recombinant monoclonal antibody, clone 9G11 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system.
Immunoprecipitation
Immunoprecipitating SHIP in Raji whole cell lysate.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human INPP5D.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human INPP5D.
Reactivity
Human
Form
Liquid
Purification
Affinity-chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry (1:50-1:200)
Immunoprecipitation(1:200-1:1000)
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: Raji whole cell lysate; Lane 2: K562 whole cell lysate.Immunohistochemistry
Immunohistochemistry image of INPP5D recombinant monoclonal antibody, clone 9G11 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system.Immunoprecipitation
Immunoprecipitating SHIP in Raji whole cell lysate.Enzyme-linked Immunoabsorbent Assay
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Gene Info — INPP5D
Entrez GeneID
3635Protein Accession#
Q92835Gene Name
INPP5D
Gene Alias
MGC104855, MGC142140, MGC142142, SHIP, SHIP1, SIP-145, hp51CN
Gene Description
inositol polyphosphate-5-phosphatase, 145kDa
Omim ID
601582Gene Ontology
HyperlinkGene Summary
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
SH2 containing inositol phosphatase|SH2 containing inositol phosphatase, isoform b|p150Ship|signaling inositol polyphosphate 5 phosphatase SIP-145
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Interactome
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Pathway
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Disease
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