Products

Western Blot (Cell lysate)

Western Blotting analysis (reducing conditions) of human INPP5D in whole cell lysate of THP-1 (human acute monocytic leukemia cell line).
Lane 1 : Immunostaining with Isotype mouse IgG1 control.
Lane 2, 3 : Immunostaining with INPP5D monoclonal antibody, clone SHIP-01 (Cat # MAB3645) Lane 4, 5 : Immunostaining with INPP5D monoclonal antibody, clone SHIP-02 (Cat # MAB3646).

Flow Cytometry

Entrez GeneID

3635

Gene Name

INPP5D

Gene Alias

MGC104855, MGC142140, MGC142142, SHIP, SHIP1, SIP-145, hp51CN

Gene Description

inositol polyphosphate-5-phosphatase, 145kDa

Omim ID

601582

Gene Ontology

Hyperlink

Gene Summary

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq

Other Designations

SH2 containing inositol phosphatase|SH2 containing inositol phosphatase, isoform b|p150Ship|signaling inositol polyphosphate 5 phosphatase SIP-145