PTPN11 recombinant monoclonal antibody, clone 6G11
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: Jurkat whole cell lysate; Lane 2: 293 whole cell lysate; Lane 3: MCF-7 whole cell lysate; Lane 4: Hela whole cell lysate; Lane 5: K562 whole cell lysate; Lane 6: HL60 whole cell lysate.
Immunohistochemistry
Immunohistochemistry image of PTPN11 recombinant monoclonal antibody, clone 6G11 diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human PTPN11.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human PTPN11.
Theoretical MW (kDa)
Calculated MW: 69, 5
Reactivity
Human
Form
Liquid
Purification
Affinity-chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: Jurkat whole cell lysate; Lane 2: 293 whole cell lysate; Lane 3: MCF-7 whole cell lysate; Lane 4: Hela whole cell lysate; Lane 5: K562 whole cell lysate; Lane 6: HL60 whole cell lysate.Immunohistochemistry
Immunohistochemistry image of PTPN11 recombinant monoclonal antibody, clone 6G11 diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTPN11
Entrez GeneID
5781Protein Accession#
Q06124Gene Name
PTPN11
Gene Alias
BPTP3, CFC, MGC14433, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Gene Description
protein tyrosine phosphatase, non-receptor type 11
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq
Other Designations
protein tyrosine phosphatase-2|protein-tyrosine phosphatase 2C
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Interactome
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Pathway
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Disease
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