PTPN11 recombinant monoclonal antibody, clone Shp2Y580-4A2 (FITC)
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More Files
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Flow Cytometry
Flow cytometric analysis of U937 cells unstained cells negative control (blue) or untreated (red) or treated with IFNa IL4 and pervanadate (green) using phospho-Shp2 (Tyr580) FITC conjugated antibody Shp2Y580-4A2.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human PTPN11.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr580 of human phospho Shp2
Reactivity
Human
Form
Liquid
Conjugation
FITC
Purification
Protein A purification, Protein G purification
Isotype
IgG
Recommend Usage
Flow Cytometry
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.09% Sodium azide, 0.2% BSA
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of U937 cells unstained cells negative control (blue) or untreated (red) or treated with IFNa IL4 and pervanadate (green) using phospho-Shp2 (Tyr580) FITC conjugated antibody Shp2Y580-4A2. -
Gene Info — PTPN11
Entrez GeneID
5781Protein Accession#
Q06124Gene Name
PTPN11
Gene Alias
BPTP3, CFC, MGC14433, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Gene Description
protein tyrosine phosphatase, non-receptor type 11
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq
Other Designations
protein tyrosine phosphatase-2|protein-tyrosine phosphatase 2C
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Interactome
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