NOTCH 1 recombinant monoclonal antibody, clone E6
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More Files
- More Functions
Immunofluorescence
Immunofluorescence analysis of NOTCH1 (green) in HeLa cell lysates using anti-Notch 1 recombinant monoclonal antibody, clone E6 (Cat # RAB02796), and DAPI(blue).
Flow Cytometry
Flow-cytometry analysis of NOTCH1 in Mouse thymocytes lysates using anti-Notch 1 recombinant monoclonal antibody, clone E6 (Cat # RAB02796).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against a fusion protein consisting of EGF domains 1–12 of murine Notch1 fused to a human Fc domain and binds to to the NRR of mouse Notch1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to a fusion protein consisting of EGF domains 1–12 of murine Notch1 fused to a human Fc domain and binds to to the NRR of mouse Notch1
Reactivity
Human, Mouse
Form
Liquid
Conjugation
Unconjugated
Concentration
batch dependent
Isotype
IgG lambda
Recommend Usage
ELISA
Flow cytometry
Immunofluorescence
Immunohistochemistry
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS with 0.02% Proclin 300
Storage Instruction
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry
Immunofluorescence
Immunofluorescence analysis of NOTCH1 (green) in HeLa cell lysates using anti-Notch 1 recombinant monoclonal antibody, clone E6 (Cat # RAB02796), and DAPI(blue).Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Flow-cytometry analysis of NOTCH1 in Mouse thymocytes lysates using anti-Notch 1 recombinant monoclonal antibody, clone E6 (Cat # RAB02796). -
Gene Info — NOTCH1
Entrez GeneID
4851Protein Accession#
P46531(human)<br>Q01705(mouse)Gene Name
NOTCH1
Gene Alias
TAN1, hN1
Gene Description
Notch homolog 1, translocation-associated (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq
Other Designations
OTTHUMP00000022594|neurogenic locus notch homolog protein 1|notch1|translocation-associated notch protein TAN-1
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Interactome
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Pathway
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Disease
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