Products

Immunofluorescence

Immunofluorescent staining of Hela cells with FOXP2 recombinant monoclonal antibody, clone RAS-S249 (Cat # RAB03473).
Immunofluorescence analysis of paraformaldehyde fixed Hela cells on Shi-fix™ coverslips stained with the chimeric r version of RAB03473 at 10 ug/mL for 1h followed by Alexa Fluor® 488 secondary antibody (2 ug/mL), showing membrane staining. The nuclear stain is DAPI (blue) and the actin stain is phalloidin (red). The isotype control was stained with an unknown specificity antibody followed by staining with Alexa Fluor® 488 secondary antibody.
(A) RAB03473
(B) DAPI
(C) Merged channels
(D) Isotype control

Enzyme-linked Immunoabsorbent Assay

Flow Cytometry

Flow cytometric analysis of HepG2 cells with FOXP2 recombinant monoclonal antibody, clone RAB-S249 (Cat # RAB03473).
HepG2 cells fixed using 2% PFA and stained with anti-unknown specificity antibody (isotype control-black line) or the r1 version of RAB03473 (blue line) at a dilution of 1:100 for 1h at RT. After washing the bound antibody was detected using a goat anti-r AlexaFluor® 488 antibody at a dilution of 1:1000 and cells analyzed using a FACSCanto flow-cytometer.

Entrez GeneID

93986

Gene Name

FOXP2

Gene Alias

CAGH44, DKFZp686H1726, SPCH1, TNRC10

Gene Description

forkhead box P2

Omim ID

602081 605317

Gene Ontology

Hyperlink

Gene Summary

This gene encodes an evolutionarily conserved transcription factor expressed in fetal and adult brain. This transcription factor is a member of the forkhead/winged-helix (FOX) family of transcription factors, and contains a FOX DNA-binding domain and a large polyglutamine tract. Members of the FOX family of transcription factors are regulators of embryogenesis. The product of this gene is thought to be required for proper development of speech and language regions of the brain during embryogenesis. Although a point mutation in this gene has been associated with the KE pedigree segregating developmental verbal dyspraxia, no association between mutations in this gene and another speech disorder, autism, has been found. Multiple alternative transcripts encoding different isoforms have been identified. [provided by RefSeq

Other Designations

CAG repeat protein 44|OTTHUMP00000067772|forkhead/winged-helix transcription factor|speech and language disorder 1|trinucleotide repeat containing 10