FOXP2 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
FOXP2 polyclonal antibody (Cat # PAB6067) staining (0.5 ug/mL) of human cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of FOXP2.
Immunogen
A synthetic peptide corresponding to C-terminus of human FOXP2.
Sequence
C-REIEEEPLSEDLE
Host
Goat
Theoretical MW (kDa)
79.9, 82.6, 70.1
Reactivity
Human, Mouse
Specificity
This antibody is expected to recognize all three reported isoforms (NP_055306.1, NP_683696.2, NP_683697.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
FOXP2 polyclonal antibody (Cat # PAB6067) staining (0.5 ug/mL) of human cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — FOXP2
Entrez GeneID
93986Protein Accession#
NP_055306.1;NP_683696.2;NP_683697.1Gene Name
FOXP2
Gene Alias
CAGH44, DKFZp686H1726, SPCH1, TNRC10
Gene Description
forkhead box P2
Gene Ontology
HyperlinkGene Summary
This gene encodes an evolutionarily conserved transcription factor expressed in fetal and adult brain. This transcription factor is a member of the forkhead/winged-helix (FOX) family of transcription factors, and contains a FOX DNA-binding domain and a large polyglutamine tract. Members of the FOX family of transcription factors are regulators of embryogenesis. The product of this gene is thought to be required for proper development of speech and language regions of the brain during embryogenesis. Although a point mutation in this gene has been associated with the KE pedigree segregating developmental verbal dyspraxia, no association between mutations in this gene and another speech disorder, autism, has been found. Multiple alternative transcripts encoding different isoforms have been identified. [provided by RefSeq
Other Designations
CAG repeat protein 44|OTTHUMP00000067772|forkhead/winged-helix transcription factor|speech and language disorder 1|trinucleotide repeat containing 10
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Interactome
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Disease
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Publication Reference
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A forkhead-domain gene is mutated in a severe speech and language disorder.
Lai CS, Fisher SE, Hurst JA, Vargha-Khadem F, Monaco AP.
Nature 2001 Oct; 413(6855):519.
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A forkhead-domain gene is mutated in a severe speech and language disorder.
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