FGB recombinant monoclonal antibody, clone 8E5
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human FGB.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic β-fibrin peptide seqeunce GHRPLDKC conjugated to MB-KLH.
Reactivity
Human
Form
Liquid
Isotype
IgG
Recommend Usage
ELISA
Flow Cytometry
In vivo Imaging
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS with 0.02% Proclin 300
Storage Instruction
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Flow cytometric analysis of HepG2 cells with FGB recombinant monoclonal antibody, clone 8E5 (Cat # RAB03449).
HepG2 cells fixed using 2% PFA and permeabilized with 0.5% Triton were stained with anti-Fluorescein IgG antibody (isotype control-black line) or the r chimeric version of RAB03449 (blue line) at a dilution of 1:100 for 1h at RT. After washing the bound antibody was detected using a goat anti-r AlexaFluor® 488 antibody at a dilution of 1:1000 and cells analyzed using a FACSCanto flow-cytometer.In vivo Imaging
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Gene Info — FGB
Entrez GeneID
2244Gene Name
FGB
Gene Alias
MGC104327, MGC120405
Gene Description
fibrinogen beta chain
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq
Other Designations
fibrinogen, B beta polypeptide|fibrinogen, beta chain
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Interactome
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