CR1 recombinant monoclonal antibody, clone E11
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CR1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against cells from acute monocytic leukemia patients.
Reactivity
Human
Form
Liquid
Isotype
IgG kappa
Recommend Usage
ELISA
Immunofluorescence
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS with 0.02% Proclin 300
Storage Instruction
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunofluorescence
Immunofluorescent staining of human peripheral blood leukocytes with CR1 recombinant monoclonal antibody, clone E11 (Cat # RAB03392).
Immunofluorescence analysis of paraformaldehyde human peripheral blood leukocytes immobilized fixed on Shi-fix™ coverslips stained with the chimeric r version of RAB03392 at 10 ug/mL followed by Alexa Fluor® 488 secondary antibody (2 ug/mL), showing membrane staining. The nuclear stain is DAPI (blue). The isotype control was stained with unknown specificity antibody followed by staining with Alexa Fluor® 488 secondary antibody.
(A) RAB03392
(B) DAPI
(C) Merged channels
(D) Isotype controlEnzyme-linked Immunoabsorbent Assay
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Gene Info — CR1
Entrez GeneID
1378Gene Name
CR1
Gene Alias
C3BR, CD35, KN
Gene Description
complement component (3b/4b) receptor 1 (Knops blood group)
Gene Ontology
HyperlinkGene Summary
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq
Other Designations
C3-binding protein|C3b/C4b receptor|CD35 antigen|Knops blood group antigen|complement component receptor 1|complement receptor 1
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Interactome
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