CASP2 recombinant monoclonal antibody
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against CASP2.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant CASP2.
Theoretical MW (kDa)
48
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of Caspase-2 and does not cross-react with related proteins.
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Flow Cytometry (1:50-1:100)
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:200)
Western Blot (1:1000-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.2 (50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at 4°C short term.
Aliquot and store at -20°C long term.
Avoid freeze-thaw cycles.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane1:293 whole cell lysate with CASP2 recombinant monoclonal antibody (Cat # RAB02699) at 1:1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using CASP2 recombinant monoclonal antibody (Cat # RAB02699).Counter stained with hematoxylin.Immunocytochemistry
Immunocytochemical staining of HeLa cells using CASP2 recombinant monoclonal antibody (Cat # RAB02699)(green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton *100/PBS.Immunofluorescence
Flow Cytometry
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Gene Info — CASP2
Entrez GeneID
835Protein Accession#
P42575Gene Name
CASP2
Gene Alias
CASP-2, ICH-1L, ICH-1L/1S, ICH1, NEDD2
Gene Description
caspase 2, apoptosis-related cysteine peptidase
Omim ID
600639Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq
Other Designations
ICH-1 protease|NEDD2 apoptosis regulatory|caspase 2|neural precursor cell expressed, developmentally down-regulated 2
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Interactome
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