Products

Western Blot

Western blot analysis of Hela (A), C6 (B), Jurkat (C), mouse colon (D), mouse gastric (E) whole cell lysates with PSEN1 recombinant monoclonal antibody (Cat # RAB02533).

Immunocytochemistry

Immunofluorescence

Immunofluorescent analysis of SKOV3 cells with PSEN1 recombinant monoclonal antibody (Cat # RAB02533). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a AF488-conjugated secondary antibody (green) in PBS at room temperature in the dark.

Immunoprecipitation

Entrez GeneID

5663

Protein Accession#

P49768

Gene Name

PSEN1

Gene Alias

AD3, FAD, PS1, S182

Gene Description

presenilin 1

Omim ID

104311 172700 600274 607822

Gene Ontology

Hyperlink

Gene Summary

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq

Other Designations

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