PSEN1 recombinant monoclonal antibody, clone R05-4D4
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More Files
- More Functions
Western Blot
Western blot analysis of Lane 1: Hela, Lane 2: C6 and Lane 3: Jurkat lysates with PSEN1 recombinant monoclonal antibody, clone R05-4D4 (Cat # RAB01985).
Immunocytochemistry
Immunocytochemical staining of SKOV-3 with PSEN1 recombinant monoclonal antibody, clone R05-4D4 (Cat # RAB01985). (A) PSEN1 (green) and (B) DAPI (blue).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human PSEN1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human PSEN1.
Theoretical MW (kDa)
Calculated MW: 53 kD
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunocytochemistry
Immunofluorescence (1:50-1:200)
Immunoprecipitation (1:20)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at -20 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1: Hela, Lane 2: C6 and Lane 3: Jurkat lysates with PSEN1 recombinant monoclonal antibody, clone R05-4D4 (Cat # RAB01985).Immunocytochemistry
Immunocytochemical staining of SKOV-3 with PSEN1 recombinant monoclonal antibody, clone R05-4D4 (Cat # RAB01985). (A) PSEN1 (green) and (B) DAPI (blue).Immunofluorescence
Immunoprecipitation
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Gene Info — PSEN1
Entrez GeneID
5663Protein Accession#
P49768Gene Name
PSEN1
Gene Alias
AD3, FAD, PS1, S182
Gene Description
presenilin 1
Gene Ontology
HyperlinkGene Summary
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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