MRE11 recombinant monoclonal antibody, clone R03-6H9
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More Files
- More Functions
Western Blot
Western Blot analysis of Lane 1: K562, Lane 2: rat brain, Lane 3: C6 and Lane 4: Hela lysates with MRE11 recombinant monoclonal antibody, clone R03-6H9 (Cat # RAB02095).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung cancer with MRE11 recombinant monoclonal antibody, clone R03-6H9 (Cat # RAB02095). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human MRE11.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human MPZ.
Theoretical MW (kDa)
Calculated MW: 81 kD
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at -20 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: K562, Lane 2: rat brain, Lane 3: C6 and Lane 4: Hela lysates with MRE11 recombinant monoclonal antibody, clone R03-6H9 (Cat # RAB02095).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lung cancer with MRE11 recombinant monoclonal antibody, clone R03-6H9 (Cat # RAB02095). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. -
Gene Info — MRE11A
Entrez GeneID
4361Protein Accession#
P49959Gene Name
MRE11A
Gene Alias
ATLD, HNGS1, MRE11, MRE11B
Gene Description
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Gene Ontology
HyperlinkGene Summary
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
AT-like disease|DNA recombination and repair protein|double-strand break repair protein MRE11A|endo/exonuclease Mre11|meiotic recombination 11 homolog A
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Interactome
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Pathway
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Disease
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