MRE11A polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis for MRE11A in 293 cells : 10 ug per lane 293 cell lysate was resolved by SDS-PAGE and the blot was probed with 2 ug/mL MRE11A polyclonal antibody (Cat # PAB0179). A protein band of approximate molecular weight of 81 KDa is detected.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MRE11A.
Immunogen
A synthetic peptide corresponding to human MRE11.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis for MRE11A in 293 cells : 10 ug per lane 293 cell lysate was resolved by SDS-PAGE and the blot was probed with 2 ug/mL MRE11A polyclonal antibody (Cat # PAB0179). A protein band of approximate molecular weight of 81 KDa is detected. -
Gene Info — MRE11A
Entrez GeneID
4361Gene Name
MRE11A
Gene Alias
ATLD, HNGS1, MRE11, MRE11B
Gene Description
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Gene Ontology
HyperlinkGene Summary
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
AT-like disease|DNA recombination and repair protein|double-strand break repair protein MRE11A|endo/exonuclease Mre11|meiotic recombination 11 homolog A
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Interactome
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Pathway
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Disease
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