MCM6 recombinant monoclonal antibody, clone R02-2I2
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More Files
- More Functions
Western Blot
Western blot analysis of MCM6 in Jurkat lysates using human MCM6 recombinant monoclonal antibody, clone R02-2I2 (Cat # RAB01746).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin-fixed paraffin-embedded sections) of Human tonsil with MCM6 recombinant monoclonal antibody, clone R02-2I2 (Cat # RAB01746).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human MCM6.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human MCM6
Theoretical MW (kDa)
Calculated MW: 93 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:100)
Immunoprecipitation (1:20)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of MCM6 in Jurkat lysates using human MCM6 recombinant monoclonal antibody, clone R02-2I2 (Cat # RAB01746).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin-fixed paraffin-embedded sections) of Human tonsil with MCM6 recombinant monoclonal antibody, clone R02-2I2 (Cat # RAB01746).Immunohistochemistry (Frozen sections)
Immunocytochemistry
Immunoprecipitation
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Gene Info — MCM6
Entrez GeneID
4175Protein Accession#
Q14566Gene Name
MCM6
Gene Alias
MCG40308, Mis5, P105MCM
Gene Description
minichromosome maintenance complex component 6
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. [provided by RefSeq
Other Designations
DNA replication licensing factor MCM6|MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)|MIS5 homolog|minichromosome maintenance deficient (mis5, S. pombe) 6|minichromosome maintenance deficient 6 homolog
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Interactome
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Pathway
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Disease
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