CCNA2/CCNA1 recombinant monoclonal antibody, clone R07-3D4
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CCNA2/CCNA1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human CCNA2/CCNA1.
Theoretical MW (kDa)
Calculated MW: 52,49
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunoprecipitation
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Acetyl-p53 (Lys370) in rat Brain lysates using Acetyl-p53 (Lys370) antibody.Western Blot
Immunocytochemistry
Immunofluorescence
Immunoprecipitation
Immunoprecipitation
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Gene Info — CCNA2
Entrez GeneID
890Protein Accession#
P20248|P78396Gene Name
CCNA2
Gene Alias
CCN1, CCNA
Gene Description
cyclin A2
Omim ID
123835Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq
Other Designations
cyclin A
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Gene Info — CCNA1
Entrez GeneID
8900Protein Accession#
P20248|P78396Gene Name
CCNA1
Gene Alias
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Gene Description
cyclin A1
Omim ID
604036Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
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Interactome
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