DEGS1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DEGS1.
Immunogen
A synthetic peptide corresponding to human DEGS1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — DEGS1
Entrez GeneID
8560Gene Name
DEGS1
Gene Alias
DEGS, DES1, Des-1, FADS7, MGC5079, MIG15, MLD
Gene Description
degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. Two splice variants have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000035598|degenerative spermatocyte homolog 1, lipid desaturase|degenerative spermatocyte homolog, lipid desaturase|dihydroceramide desaturase|membrane fatty acid (lipid) desaturase|migration-inducing gene 15 protein|sphingolipid delta 4 desatura
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Interactome
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Pathway
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Publication Reference
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Identification and characterization of a sphingolipid delta 4-desaturase family.
Ternes P, Franke S, Zähringer U, Sperling P, Heinz E.
The Journal of Biological Chemistry 2002 Jul; 277(28):25512.
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The product of the MLD gene is a member of the membrane fatty acid desaturase family: overexpression of MLD inhibits EGF receptor biosynthesis.
Cadena DL, Kurten RC, Gill GN.
Biochemistry 1997 Jun; 36(23):6960.
Application：IF, WB-Ce, WB-Tr, Human, Monkey, HeLa, CV1, 293 EBNA cells.
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Identification and characterization of a sphingolipid delta 4-desaturase family.
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