Snca (phospho S129) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of Snca.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S129 of rat Snca.
Host
Rabbit
Theoretical MW (kDa)
15
Reactivity
Bovine, Dog, Human, Mouse, Primates, Rat
Form
Liquid
Purification
Affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of rat cortex lysate showing specific labeling of the ~15 k Snca protein phosphorylated at Ser129. Immunolabeling is blocked by the phosphopeptide (peptide) used as antigen but not by the corresponding dephosphopeptide (not shown). -
Gene Info — Snca
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Publication Reference
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Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease.
Masliah E, Rockenstein E, Adame A, Alford M, Crews L, Hashimoto M, Seubert P, Lee M, Goldstein J, Chilcote T, Games D, Schenk D.
Neuron 2005 Jun; 46(6):857.
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Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.
Smith WW, Margolis RL, Li X, Troncoso JC, Lee MK, Dawson VL, Dawson TM, Iwatsubo T, Ross CA.
The Journal of Neuroscience 2005 Jun; 25(23):5544.
Application:WB-Tr, Human, SH-SY5Y cells.
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Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.
Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C.
The Journal of Clinical Investigation 2002 Nov; 110(10):1429.
Application:IHC-P, WB-Ti, Human, Mouse, Brain.
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Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease.
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