ABI1 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ABI1.
Immunogen
A synthetic peptide corresponding to amino acids at C-terminus of human ABI1.
Host
Rabbit
Theoretical MW (kDa)
55.1
Reactivity
Human, Mouse, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
Immunohistochemistry (Frozen sections) (0.5-1 ug/mL)
Immunocytochemistry (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
Western blot analysis of rat brain tissue lysate. Using ABI1 polyclonal antibody (Cat # PAB7947) .Immunofluorescence
Immunofluorescence analysis of paraffin-embedded rat brain tissue sections, staining ABI1 in cytoplasm by SABC-FITC. -
Gene Info — ABI1
Entrez GeneID
10006Gene Name
ABI1
Gene Alias
ABI-1, E3B1, NAP1BP, SSH3BP, SSH3BP1
Gene Description
abl-interactor 1
Omim ID
603050Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq
Other Designations
Abelson interactor 1|Abl-interactor protein 1 long|OTTHUMP00000019352|OTTHUMP00000019355|eps8 binding protein|interactor protein AblBP4|nap1 binding protein|spectrin SH3 domain binding protein 1
-
Interactome
-
Disease
-
Publication Reference
-
AlphaII-spectrin participates in the surface expression of cell adhesion molecule L1 and neurite outgrowth.
Trinh-Trang-Tan MM, Bigot S, Picot J, Lecomte MC, Kordeli E.
Experimental Cell Research 2014 Apr; 322(2):365.
Application:WB-Tr, Human, SH-SY5Y cells.
-
Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development.
McNeill EM, Klockner-Bormann M, Roesler EC, Talton LE, Moechars D, Clagett-Dame M.
Developmental Biology 2011 May; 353(2):331.
Application:IHC, Mouse, Brain.
-
Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase.
Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T.
The Journal of Biological Chemistry 2003 Jun; 278(24):21685.
Application:IF, Mouse, Fibroblasts.
-
ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23).
Taki T, Shibuya N, Taniwaki M, Hanada R, Morishita K, Bessho F, Yanagisawa M, Hayashi Y.
Blood 1998 Aug; 92(4):1125.
-
AlphaII-spectrin participates in the surface expression of cell adhesion molecule L1 and neurite outgrowth.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com