NPEPPS polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
NPEPPS polyclonal antibody (Cat # PAB7579) (0.3 ug/mL) staining of human brain (cerebral cortex) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NPEPPS.
Immunogen
A synthetic peptide corresponding to human NPEPPS.
Sequence
C-KRDAESIHQYLLQRK
Host
Goat
Theoretical MW (kDa)
98.5
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000)
Western Blot (0.2-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
NPEPPS polyclonal antibody (Cat # PAB7579) (0.3 ug/mL) staining of human brain (cerebral cortex) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NPEPPS
Entrez GeneID
9520Protein Accession#
NP_006301.2Gene Name
NPEPPS
Gene Alias
MP100, PSA
Gene Description
aminopeptidase puromycin sensitive
Omim ID
606793Gene Ontology
HyperlinkGene Summary
This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq
Other Designations
metalloproteinase MP100|puromycin-sensitive aminopeptidase
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Interactome
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Publication Reference
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A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration.
Karsten SL, Sang TK, Gehman LT, Chatterjee S, Liu J, Lawless GM, Sengupta S, Berry RW, Pomakian J, Oh HS, Schulz C, Hui KS, Wiedau-Pazos M, Vinters HV, Binder LI, Geschwind DH, Jackson GR.
Neuron 2006 Sep; 51(5):549.
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A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration.
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