PTPRM polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PTPRM.
Immunogen
A synthetic peptide corresponding to human PTPRM.
Sequence
C-KLIRQVDKWQEEYN
Host
Goat
Theoretical MW (kDa)
165, 164
Specificity
This antibody is expected to recognize both reported isoforms (NP_001098714.1 and NP_002836.3).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTPRM
Entrez GeneID
5797Protein Accession#
NP_001098714.1;NP_002836.3Gene Name
PTPRM
Gene Alias
MGC166994, PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu
Gene Description
protein tyrosine phosphatase, receptor type, M
Omim ID
176888Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq
Other Designations
protein tyrosine phosphatase mu|protein tyrosine phosphatase, receptor type, mu polypeptide
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Interactome
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Pathway
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Disease
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Publication Reference
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Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion.
Aricescu AR, Hon WC, Siebold C, Lu W, van der Merwe PA, Jones EY.
The EMBO Journal 2006 Feb; 25(4):701.
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Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion.
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