CYTH2 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
CYTH2 polyclonal antibody (Cat # PAB7405) (0.5 ug/mL) staining of human brain (cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CYTH2.
Immunogen
A synthetic peptide corresponding to human CYTH2.
Sequence
EDGVYEPPDLTP-C
Host
Goat
Theoretical MW (kDa)
46.5, 46.5
Reactivity
Human, Rat
Specificity
This antibody is expected to recognize both reported isoforms (NP_004219.2, NP_059431.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CYTH2 polyclonal antibody (Cat # PAB7405) (0.5 ug/mL) staining of human brain (cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CYTH2
Entrez GeneID
9266Protein Accession#
NP_004219.2;NP_059431.1Gene Name
CYTH2
Gene Alias
ARNO, CTS18, CTS18.1, PSCD2, PSCD2L, SEC7L, Sec7p-L, Sec7p-like
Gene Description
cytohesin 2
Omim ID
602488Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
ARF exchange factor|ARF nucleotide-binding site opener|pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)|pleckstrin homology, Sec7 and coiled-coil domains 2-like|pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2)
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Interactome
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Publication Reference
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Guanine nucleotide exchange factors of the cytohesin family and their roles in signal transduction.
Kolanus W.
Immunological Reviews 2007 Aug; 218:102.
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Guanine nucleotide exchange factors of the cytohesin family and their roles in signal transduction.
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