BAG5 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of BAG5.
Immunogen
A synthetic peptide corresponding to human BAG5.
Sequence
C-DGNRTDKNYIR
Host
Goat
Theoretical MW (kDa)
56.0, 51.2
Specificity
This antibody is expected to recognize reported isoforms a (NP_001015049.1) and b (NP_001015048.1, NP_004864.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — BAG5
Entrez GeneID
9529Protein Accession#
NP_001015048.1;NP_001015049.1;NP_004864.1Gene Name
BAG5
Gene Alias
BAG-5
Gene Description
BCL2-associated athanogene 5
Omim ID
603885Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
BAG-family molecular chaperone regulator-5
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Interactome
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Disease
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Publication Reference
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BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.
Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM.
Neuron 2004 Dec; 44(6):931.
Application:IF, IHC, WB, Human, Mouse, Brains, HEK 293T, SH-SY5Y cells.
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BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.
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