TPD52L1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TPD52L1.
Immunogen
A synthetic peptide corresponding to human TPD52L1.
Sequence
C-EPLQGTDEDAVASAD
Host
Goat
Theoretical MW (kDa)
22.5, 16.2, 14.7
Reactivity
Human
Specificity
This antibody is expected to recognize isoforms 1, 3 and 4 (NP_003278.1, NP_001003396.1 and NP_001003397.1 resp.).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
TPD52L1 polyclonal antibody (Cat # PAB7361) (0.1 ug/mL) staining of human breast cancer lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TPD52L1
Entrez GeneID
7164Protein Accession#
NP_003278.1;NP_001003395.1;NP_001003396.1;NP_001003397.1Gene Name
TPD52L1
Gene Alias
D53, MGC8556, TPD52L2, hD53
Gene Description
tumor protein D52-like 1
Omim ID
604069Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined. [provided by RefSeq
Other Designations
OTTHUMP00000017133|OTTHUMP00000017135|OTTHUMP00000017136|tumor protein D52-like 2|tumor protein D53
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Interactome
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Publication Reference
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Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins.
Boutros R, Bailey AM, Wilson SH, Byrne JA.
Journal of Molecular Biology 2003 Sep; 332(3):675.
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Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins.
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