ACTR1A polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
ACTR1A polyclonal antibody (Cat # PAB6617) staining (1 ug/mL) of human brain lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ACTR1A.
Immunogen
A synthetic peptide corresponding to human ACTR1A.
Sequence
C-YEEDGARSIHRKT
Host
Goat
Theoretical MW (kDa)
42.6
Reactivity
Human
Specificity
This epitope was selected to minimise the chance of cross-reactivity with ACTR1B (YEEDGSRAIHRKT).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
ACTR1A polyclonal antibody (Cat # PAB6617) staining (1 ug/mL) of human brain lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ACTR1A
Entrez GeneID
10121Protein Accession#
NP_005727.1Gene Name
ACTR1A
Gene Alias
ARP1, CTRN1, FLJ52695, FLJ52800, FLJ55002
Gene Description
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
Omim ID
605143Gene Ontology
HyperlinkGene Summary
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq
Other Designations
ARP1 actin-related protein 1 homolog A, centractin alpha|ARP1, yeast homolog A|OTTHUMP00000020366|actin-RPV|centractin alpha|centrosome-associated actin homolog
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Interactome
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Publication Reference
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A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility.
Lees-Miller JP, Helfman DM, Schroer TA.
Nature 1992 Sep; 359(6392):244.
Application：WB-Re, WB-Ti, Human, Rat, Rat brains, Recombinant proteins.
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A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility.
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