MLL4 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
MLL4 polyclonal antibody (Cat # PAB6291) (5 ug/mL) staining of paraffin embedded human testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of MLL4.
Immunogen
A synthetic peptide corresponding to human MLL4.
Sequence
CNCGAKRCRRFLN
Host
Goat
Theoretical MW (kDa)
312
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
MLL4 polyclonal antibody (Cat # PAB6291) (5 ug/mL) staining of paraffin embedded human testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MLL4
Entrez GeneID
9757Protein Accession#
NP_055542Gene Name
MLL4
Gene Alias
HRX2, KIAA0304, MLL2, TRX2, WBP7
Gene Description
myeloid/lymphoid or mixed-lineage leukemia 4
Omim ID
606834Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq
Other Designations
WW domain binding protein 7|mixed lineage leukemia gene homolog 2|trithorax homologue 2
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Interactome
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Publication Reference
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Dynamic regulation of BDNF gene expression by estradiol and lncRNA HOTAIR.
Paromita Deb, Avisankar Chini, Prarthana Guha, Ashcharya Rishi, Arunoday Bhan, Blake Brady, Linda I Perrotti, Subhrangsu S Mandal.
Gene 2024 Mar; 897:148055.
Application：ChIP, Mouse, HT22 cells.
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MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines.
Huntsman DG, Chin SF, Muleris M, Batley SJ, Collins VP, Wiedemann LM, Aparicio S, Caldas C.
Oncogene 1999 Dec; 18(56):7975.
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Dynamic regulation of BDNF gene expression by estradiol and lncRNA HOTAIR.
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