SETDB2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
SETDB2 polyclonal antibody (Cat # PAB6288) (0.3 ug/mL) staining of Nuclear HeLa lysate (35 ug protein in RIPA buffer). Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SETDB2.
Immunogen
A synthetic peptide corresponding to human SETDB2.
Sequence
GEKNGDAKTFWME-C
Host
Goat
Theoretical MW (kDa)
81.9, 80.7
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:1000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
SETDB2 polyclonal antibody (Cat # PAB6288) (0.3 ug/mL) staining of Nuclear HeLa lysate (35 ug protein in RIPA buffer). Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SETDB2
Entrez GeneID
83852Protein Accession#
NP_114121.1Gene Name
SETDB2
Gene Alias
C13orf4, CLLD8, CLLL8, DKFZp586I0123, DKFZp761J1217, KMT1F
Gene Description
SET domain, bifurcated 2
Omim ID
607865Gene Ontology
HyperlinkGene Summary
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM
Other Designations
CLLL8 protein|OTTHUMP00000018417
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Interactome
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Pathway
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Disease
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Publication Reference
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Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia.
Mabuchi H, Fujii H, Calin G, Alder H, Negrini M, Rassenti L, Kipps TJ, Bullrich F, Croce CM.
Cancer Research 2001 Apr; 61(7):2870.
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Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia.
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