TBL1X/TBL1XR1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
The TBL1X/TBL1XR1 polyclonal antibody (Cat # PAB6110) staining (4 ug/mL) of human brain lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TBL1X/TBL1XR1.
Immunogen
A synthetic peptide corresponding to human TBL1X, TBL1XR1.
Sequence
SASDGSVCVLDLRK
Host
Goat
Theoretical MW (kDa)
62.5, 57.0, 55.6
Reactivity
Human
Specificity
This antibody is also expected to recognize the human protein TBLR1 (NP_078941), which is very similar.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000)
Western blot (3-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The TBL1X/TBL1XR1 polyclonal antibody (Cat # PAB6110) staining (4 ug/mL) of human brain lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TBL1X
Entrez GeneID
6907Protein Accession#
NP_005638.1 (Gene ID : 6907);NP_078941.2 (Gene ID : 79718)Gene Name
TBL1X
Gene Alias
EBI, SMAP55, TBL1
Gene Description
transducin (beta)-like 1X-linked
Omim ID
300196Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq
Other Designations
F-box-like/WD repeat-containing protein TBL1X|OTTHUMP00000022880|transducin beta-like 1X
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Gene Info — TBL1XR1
Entrez GeneID
79718Protein Accession#
NP_005638.1 (Gene ID : 6907);NP_078941.2 (Gene ID : 79718)Gene Name
TBL1XR1
Gene Alias
C21, DC42, FLJ12894, IRA1, TBLR1
Gene Description
transducin (beta)-like 1 X-linked receptor 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. [provided by RefSeq
Other Designations
TBL1-related protein 1|nuclear receptor co-repressor/HDAC3 complex subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival.
Hoberg JE, Yeung F, Mayo MW.
Molecular Cell 2004 Oct; 16(2):245.
Application：WB, Human, DU 145, HEK 293T cells.
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SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival.
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