PGAM1/PGAM2/PGAM4 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PGAM1/PGAM2/PGAM4.
Immunogen
A synthetic peptide corresponding to human PGAM1, PGAM2, PGAM4.
Sequence
C-KAMEAVAAQGKAKK
Host
Goat
Theoretical MW (kDa)
28.8
Reactivity
Human
Specificity
This antibody is expected to recognize the products of 3 highly similar genes.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.01-0.03 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The PGAM1/PGAM2/PGAM4 polyclonal antibody (Cat # PAB6005) staining (0.01 ug/mL) of human liver lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PGAM1
Entrez GeneID
5223Protein Accession#
NP_002620.1 (Gene ID : 5223);NP_000281.2 (Gene ID : 5224);NP_001025062.1 (Gene ID : 441531)Gene Name
PGAM1
Gene Alias
PGAM-B, PGAMA
Gene Description
phosphoglycerate mutase 1 (brain)
Omim ID
172250Gene Ontology
HyperlinkGene Summary
nonmuscle form
Other Designations
OTTHUMP00000020190|OTTHUMP00000059414|phosphoglycerate mutase A, nonmuscle form
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Gene Info — PGAM2
Entrez GeneID
5224Protein Accession#
NP_002620.1 (Gene ID : 5223);NP_000281.2 (Gene ID : 5224);NP_001025062.1 (Gene ID : 441531)Gene Name
PGAM2
Gene Alias
MGC88743, PGAM-M, PGAMM
Gene Description
phosphoglycerate mutase 2 (muscle)
Omim ID
261670Gene Ontology
HyperlinkGene Summary
Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq
Other Designations
Phosphoglycerate mutase, muscle form
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Gene Info — PGAM4
Entrez GeneID
441531Protein Accession#
NP_002620.1 (Gene ID : 5223);NP_000281.2 (Gene ID : 5224);NP_001025062.1 (Gene ID : 441531)Gene Name
PGAM4
Gene Alias
PGAM-B, PGAM1, PGAM3, dJ1000K24.1
Gene Description
phosphoglycerate mutase family member 4
Omim ID
300567Gene Ontology
HyperlinkOther Designations
OTTHUMP00000063546|phosphoglycerate mutase family 3|phosphoglycerate mutase family 4|phosphoglycerate mutase processed protein
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Interactome
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Pathway
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine
- Biosynthesis of alkaloids derived from ornithine
- Biosynthesis of alkaloids derived from ornithine
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from shikimate pathway
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Publication Reference
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Isolation of a cDNA encoding the B isozyme of human phosphoglycerate mutase (PGAM) and characterization of the PGAM gene family.
Sakoda S, Shanske S, DiMauro S, Schon EA.
The Journal of Biological Chemistry 1988 Nov; 263(32):16899.
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Isolation of a cDNA encoding the B isozyme of human phosphoglycerate mutase (PGAM) and characterization of the PGAM gene family.
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