MYB polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MYB.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to human MYB.
Sequence
PLLKKIKQEVESPTCA
Host
Rabbit
Reactivity
Mouse
Specificity
This antibody recognize synthetic peptide (PLLKKIKQEVESPTCA) containing a predicted sumoylation site of human MYB.
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse heart tissue lysate (35 ug/lane) with MYB polyclonal antibody (Cat # PAB4338).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with MYB polyclonal antibody (Cat # PAB4338) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma . -
Gene Info — MYB
Entrez GeneID
4602Protein Accession#
CAE55174;P10242Gene Name
MYB
Gene Alias
Cmyb, c-myb, c-myb_CDS, efg
Gene Description
v-myb myeloblastosis viral oncogene homolog (avian)
Omim ID
189990Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
Avian myeloblastosis viral (v-myb) oncogene homolog|OTTHUMP00000017258|c-myb protein (140 AA)|c-myb10A_CDS|c-myb13A_CDS|c-myb14A_CDS|c-myb8B_CDS|v-myb avian myeloblastosis viral oncogene homolog|v-myb myeloblastosis viral oncogene homolog
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Interactome
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Disease
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Publication Reference
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Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner.
Dahle O, Andersen TO, Nordgard O, Matre V, Del Sal G, Gabrielsen OS.
European Journal of Biochemistry 2003 Mar; 270(6):1338.
Application:IP, WB-Tr, Monkey, CV-1 cells.
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Characterization of the c-Myb-responsive region and regulation of the human type I collagen alpha 2 chain gene by c-Myb.
Luchetti MM, Paroncini P, Majlingova P, Frampton J, Mucenski M, Baroni SS, Sambo P, Golay J, Introna M, Gabrielli A.
The Journal of Biological Chemistry 2002 Nov; 278(3):1533.
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A Myb dependent pathway maintains Friend murine erythroleukemia cells in an immature and proliferating state.
Chen J, Kremer CS, Bender TP.
Oncogene 2002 Mar; 21(12):1859.
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Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner.
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