NPR3 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of NPR3 polyclonal antibody (Cat # PAB3331) in HL-60 cell lysate. NPR3 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with NPR3 polyclonal antibody (Cat # PAB3331) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NPR3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human NPR3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunofluorescence (1:200)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:10-50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NPR3 polyclonal antibody (Cat # PAB3331) in HL-60 cell lysate. NPR3 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with NPR3 polyclonal antibody (Cat # PAB3331) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.Immunofluorescence
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Gene Info — NPR3
Entrez GeneID
4883Protein Accession#
P17342 (Precursor)Gene Name
NPR3
Gene Alias
ANPRC, GUCY2B, NPRC
Gene Description
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
Omim ID
108962Gene Ontology
HyperlinkGene Summary
The family of natriuretic peptides (see MIM 108780) elicit a number of vascular, renal, and endocrine effects that are important in the maintenance of blood pressure and extracellular fluid volume. These effects are mediated by specific binding of the peptides to cell surface receptors in the vasculature, kidney, adrenal, and brain.[supplied by OMIM
Other Designations
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Interactome
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Disease
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Publication Reference
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Isolation and functional expression of the human atrial natriuretic peptide clearance receptor cDNA.
Porter JG, Arfsten A, Fuller F, Miller JA, Gregory LC, Lewicki JA.
Biochemical and Biophysical Research Communications 1990 Sep; 171(2):796.
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cDNA sequence of the human atrial natriuretic peptide clearance receptor.
Lowe DG, Camerato TR, Goeddel DV.
Nucleic Acids Research 1990 Jun; 18(11):3412.
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Isolation and functional expression of the human atrial natriuretic peptide clearance receptor cDNA.
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