PPL polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of PPL polyclonal antibody (Cat # PAB28501) in T47D cell line lysates (35ug/lane). PPL (arrow) was detected using the purified polyclonal antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human skin tissue with PPL polyclonal antibody (Cat # PAB28501) followed by peroxidase conjugation of the secondary antibody and DAB staining.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PPL.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 1301-1330 at C-terminal region at human PPL.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Immunohistochemistry (1:10-50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PPL polyclonal antibody (Cat # PAB28501) in T47D cell line lysates (35ug/lane). PPL (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human skin tissue with PPL polyclonal antibody (Cat # PAB28501) followed by peroxidase conjugation of the secondary antibody and DAB staining. -
Gene Info — PPL
Entrez GeneID
5493Protein Accession#
O60437Gene Name
PPL
Gene Alias
KIAA0568, MGC134872
Gene Description
periplakin
Omim ID
602871Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq
Other Designations
190 kDa paraneoplastic pemphigus antigen|195 kDa cornified envelope|OTTHUMP00000159922
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Interactome
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Disease
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