FLT3 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of FLT3 in NIH/3T3 cell lysate with FLT3 polyclonal antibody (Cat # PAB25628) at (1) 1 and (2) 2 ug/mL.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FLT3.
Immunogen
A synthetic peptide corresponding to 18 amino acids at internal region of human FLT3.
Host
Rabbit
Theoretical MW (kDa)
109
Reactivity
Human, Mouse
Specificity
At least three isoforms of FLT3 are known to exist; this antibody will detect all isoforms.
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of FLT3 in NIH/3T3 cell lysate with FLT3 polyclonal antibody (Cat # PAB25628) at (1) 1 and (2) 2 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — FLT3
Entrez GeneID
2322Protein Accession#
NP_004110Gene Name
FLT3
Gene Alias
CD135, FLK2, STK1
Gene Description
fms-related tyrosine kinase 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq
Other Designations
CD135 antigen|FL cytokine receptor|FLT3 receptor tyrosine kinase|OTTHUMP00000042340|fetal liver kinase 2|growth factor receptor tyrosine kinase type III|stem cell tyrosine kinase 1|tyrosine-protein kinase receptor FLT3
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Interactome
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Pathway
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Disease
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