NBN polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NBN.
Immunogen
A synthetic peptide corresponding to N-terminus of human NBN.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
At least three alternatively spliced transcript isoforms of NIBRIN are known to exist.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (2.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of rat lung tissue lysate with NBN polyclonal antibody (Cat # PAB25488) at (1) 1 and (2) 2 ug/mL.Immunohistochemistry
Immunohistochemical anyalysis of human lung tissue with NBN polyclonal antibody (Cat # PAB25488) at 2.5 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NBN
Entrez GeneID
4683Protein Accession#
NP_002476Gene Name
NBN
Gene Alias
AT-V1, AT-V2, ATV, FLJ10155, MGC87362, NBS, NBS1, P95
Gene Description
nibrin
Gene Ontology
HyperlinkGene Summary
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq
Other Designations
Nijmegen breakage syndrome 1 (nibrin)|cell cycle regulatory protein p95|p95 protein of the MRE11/RAD50 complex
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Interactome
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Pathway
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Disease
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