FGD4 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against recombinant FGD4.
Immunogen
Recombinant protein corresponding to amino acids of human FGD4.
Sequence
EPLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQ
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:20-1:50)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human testis with FGD4 polyclonal antibody (Cat # PAB23406) shows distinct cytoplasmic positivity in cells in seminiferus ducts.Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with FGD4 polyclonal antibody (Cat # PAB23406) at 1-4 ug/mL dilution shows positivity in cytoskeleton (actin filaments). -
Gene Info — FGD4
Entrez GeneID
121512Protein Accession#
Q96M96Gene Name
FGD4
Gene Alias
CMT4H, DKFZp313E1818, DKFZp434K1572, FLJ34370, FLJ42663, FRABP, MGC57222, ZFYVE6
Gene Description
FYVE, RhoGEF and PH domain containing 4
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq
Other Designations
FGD1 family, member 4|FGD1-related F-actin-binding protein|actin-filament binding protein frabin|zinc finger FYVE domain-containing protein 6
-
Interactome
-
Disease
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com