Products

Western Blot

Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with CD2AP polyclonal antibody (Cat # PAB20186) at 1:250-1:500 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human colon with CD2AP polyclonal antibody (Cat # PAB20186) shows strong cytoplasmic positivity in glandular cells at 1:50-1:200 dilution.

Immunofluorescence

Immunofluorescent staining of human cell line U-251 MG with CD2AP polyclonal antibody (Cat # PAB20186) at 1-4 ug/mL dilution shows positivity in plasma membrane, cytoplasm.

Entrez GeneID

23607

Protein Accession#

Q9Y5K6

Gene Name

CD2AP

Gene Alias

CMS, DKFZp586H0519

Gene Description

CD2-associated protein

Omim ID

604241 607832

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq

Other Designations

Cas ligand with multiple Src homology 3 (SH3) domains|adapter protein CMS