TOP1MT polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human cerebral cortex with TOP1MT polyclonal antibody (Cat # PAB20098) shows strong nuclear and cytoplasmic positivity in neuronal cells.
Immunofluorescence
Immunofluorescent staining of human cell line A-431 with TOP1MT polyclonal antibody (Cat # PAB20098) at 1-4 ug/mL dilution shows positivity in mitochondria.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant TOP1MT.
Immunogen
Recombinant protein corresponding to amino acids of human TOP1MT.
Sequence
GYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQ
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human cerebral cortex with TOP1MT polyclonal antibody (Cat # PAB20098) shows strong nuclear and cytoplasmic positivity in neuronal cells.Immunofluorescence
Immunofluorescent staining of human cell line A-431 with TOP1MT polyclonal antibody (Cat # PAB20098) at 1-4 ug/mL dilution shows positivity in mitochondria. -
Gene Info — TOP1MT
Entrez GeneID
116447Protein Accession#
Q969P6Gene Name
TOP1MT
Gene Alias
2900052H09Rik
Gene Description
topoisomerase (DNA) I, mitochondrial
Omim ID
606387Gene Ontology
HyperlinkGene Summary
This gene encodes a mitochondrial DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of DNA which allows the strands to pass through one another and relieves the stress introduced by a circular mitochondrial genome during replication and transcription. [provided by RefSeq
Other Designations
mitochondrial topoisomerase I
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Interactome
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Disease
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