NLRP4 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of NLRP4 in K-562 cell lysate with NLRP4 polyclonal antibody (Cat # PAB19302) at 1 ug/mL.
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Specification
Product Description
Rabbit polyclonal antibody rasied against synthetic peptide of NLRP4.
Immunogen
A synthetic peptide corresponding to 13 amino acids near center region of human NLRP4.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NLRP4 in K-562 cell lysate with NLRP4 polyclonal antibody (Cat # PAB19302) at 1 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NLRP4
Entrez GeneID
147945Protein Accession#
AAL35293Gene Name
NLRP4
Gene Alias
CLR19.5, FLJ32126, NALP4, PAN2, PYPAF4, RNH2
Gene Description
NLR family, pyrin domain containing 4
Omim ID
609645Gene Ontology
HyperlinkGene Summary
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM
Other Designations
NACHT, LRR and PYD containing protein 4|NACHT, leucine rich repeat and PYD containing 4|PAAD and NACHT-containing protein 2|PYRIN-containing APAF1-like protein 4|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4|
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Disease
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