SGK1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from Jurkat cells, using SGK1 polyclonal antibody (Cat # PAB18136).
Peptide "+" means "peptide blocking".
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using SGK1 polyclonal antibody (Cat # PAB18136).
Peptide "+" means "peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SGK1.
Immunogen
A synthetic peptide corresponding to human SGK1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to SGK1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from Jurkat cells, using SGK1 polyclonal antibody (Cat # PAB18136).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using SGK1 polyclonal antibody (Cat # PAB18136).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — SGK1
Entrez GeneID
6446Protein Accession#
O00141Gene Name
SGK1
Gene Alias
SGK
Gene Description
serum/glucocorticoid regulated kinase 1
Omim ID
602958Gene Ontology
HyperlinkGene Summary
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000017247|serine/threonine protein kinase SGK
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Interactome
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Disease
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Publication Reference
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SGK protein kinase facilitates the expression of long-term potentiation in hippocampal neurons.
Ma YL, Tsai MC, Hsu WL, Lee EH.
Learning & Memory (Cold Spring Harbor, N.Y.) 2006 Mar; 13(2):114.
Application：WB-Tr, Rat, Rat hippocampal neurons.
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Hypotonic activation of volume-sensitive outwardly rectifying chloride channels in cultured PASMCs is modulated by SGK.
Wang GX, McCrudden C, Dai YP, Horowitz B, Hume JR, Yamboliev IA.
American Journal of Physiology. Heart and Circulatory Physiology 2004 Aug; 287(2):H533.
Application：WB, Dog, Dog pulmonary artery smooth muscle cells.
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Activation of serum- and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulin.
Perrotti N, He RA, Phillips SA, Haft CR, Taylor SI.
Journal of Biological Chemistry 2001 Mar; 276(12):9406.
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SGK protein kinase facilitates the expression of long-term potentiation in hippocampal neurons.
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