NRGN polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
NRGN polyclonal antibody (Cat # PAB17274) (0.1 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
NRGN polyclonal antibody (Cat # PAB17274) (3.8 ug/mL) staining of paraffin embedded human cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NRGN.
Immunogen
A synthetic peptide corresponding to internal region of human NRGN.
Sequence
C-KIKSGERGRKG
Host
Goat
Theoretical MW (kDa)
7.6
Reactivity
Human, Mouse, Rat
Specificity
Reported variants represent identical protein: NP_006167.1, NP_001119653.1.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western Blot (0.1-0.3 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
NRGN polyclonal antibody (Cat # PAB17274) (0.1 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
NRGN polyclonal antibody (Cat # PAB17274) (3.8 ug/mL) staining of paraffin embedded human cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NRGN
Entrez GeneID
4900Protein Accession#
NP_006167.1Gene Name
NRGN
Gene Alias
RC3, hng
Gene Description
neurogranin (protein kinase C substrate, RC3)
Omim ID
602350Gene Ontology
HyperlinkGene Summary
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq
Other Designations
calmodulin-binding protein|neurogranin|protein kinase C substrate
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Interactome
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Disease
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Publication Reference
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Association of the gene encoding neurogranin with schizophrenia in males.
Ruano D, Aulchenko YS, Macedo A, Soares MJ, Valente J, Azevedo MH, Hutz MH, Gama CS, Lobato MI, Belmonte-de-Abreu P, Goodman AB, Pato C, Heutink P, Palha JA.
Journal of Psychiatric Research 2006 Nov; 42(2):125.
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Association of the gene encoding neurogranin with schizophrenia in males.
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