NRGN DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human NRGN DNA using DNAx™ Immune technology.
Technology
Immunogen
Full-length human DNA
Sequence
MDCCTENACSKPDDDILDIPLDDPGANAAAAKIQASFRGHMARKKIKSGERGRKGPGPGGPGGAGVARGGAGGGPSGD
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — NRGN
Entrez GeneID
4900GeneBank Accession#
NM_006176.1Protein Accession#
NP_006167.1Gene Name
NRGN
Gene Alias
RC3, hng
Gene Description
neurogranin (protein kinase C substrate, RC3)
Omim ID
602350Gene Ontology
HyperlinkGene Summary
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq
Other Designations
calmodulin-binding protein|neurogranin|protein kinase C substrate
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Interactome
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Disease
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