GSTA1 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against recombinant GSTA1.
Immunogen
Recombinant protein corresponding to human GSTA1.
Host
Rabbit
Reactivity
Human, Rat
Specificity
Specific for the alpha form (human and rat). Minimal cross-reactivity with the pi form of GST, but does not cross-react with the mu form of GST. Reactive with 0.2 g of recombinant human GST A1-1.
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.5
Storage Instruction
Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
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Gene Info — GSTA1
Entrez GeneID
2938Gene Name
GSTA1
Gene Alias
GST2, GSTA1-1, GTH1, MGC131939
Gene Description
glutathione S-transferase alpha 1
Omim ID
138359Gene Ontology
HyperlinkGene Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq
Other Designations
GST, class alpha, 1|GST-epsilon|OTTHUMP00000016611|S-(hydroxyalkyl)glutathione lyase A1|glutathione S-alkyltransferase A1|glutathione S-aryltransferase A1|glutathione S-transferase 2|glutathione S-transferase A1|glutathione S-transferase Ha subunit 1
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Glutathione-s-transferase pi expression in leukaemia: a comparative analysis with mdr-1 data.
Holmes J, Wareing C, Jacobs A, Hayes JD, Padua RA, Wolf CR.
British Journal of Cancer 1990 Aug; 62(2):209.
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Glutathione-s-transferase pi expression in leukaemia: a comparative analysis with mdr-1 data.
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