RHEB polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of RHEB in mouse brain tissue lysate with RHEB polyclonal antibody (Cat # PAB13143) at (A) 1, (B) 2, and (C) 4 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of RHEB in mouse brain tissue with RHEB polyclonal antibody (Cat # PAB13143) at 2 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RHEB.
Immunogen
A synthetic peptide corresponding to internal region 15 amino acids of human RHEB.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of RHEB in mouse brain tissue lysate with RHEB polyclonal antibody (Cat # PAB13143) at (A) 1, (B) 2, and (C) 4 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of RHEB in mouse brain tissue with RHEB polyclonal antibody (Cat # PAB13143) at 2 ug/mL . -
Gene Info — RHEB
Entrez GeneID
6009Protein Accession#
AAH16155Gene Name
RHEB
Gene Alias
MGC111559, RHEB2
Gene Description
Ras homolog enriched in brain
Omim ID
601293Gene Ontology
HyperlinkGene Summary
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq
Other Designations
GTP-binding protein Rheb|Ras homolog enriched in brain 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Inoki K, Li Y, Xu T, Guan KL.
Genes & Development 2003 Jul; 17(15):1829.
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Rheb is an essential regulator of S6K in controlling cell growth in Drosophila.
Stocker H, Radimerski T, Schindelholz B, Wittwer F, Belawat P, Daram P, Breuer S, Thomas G, Hafen E.
Nature Cell Biology 2003 Jun; 5(6):559.
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rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.
Yamagata K, Sanders LK, Kaufmann WE, Yee W, Barnes CA, Nathans D, Worley PF.
The Journal of Biological Chemistry 1994 Jun; 269(23):16333.
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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
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