BRCC3 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of BRCC3 in MCF-7 cell lysate with BRCC3 polyclonal antibody (Cat # PAB13012) at (A) 0.5, (B) 1 and (C) 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of BRCC3 in human brain tissue with BRCC3 polyclonal antibody (Cat # PAB13012) at 2.5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BRCC3.
Immunogen
A synthetic peptide corresponding to N-terminus 18 amino acids of human BRCC3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of BRCC3 in MCF-7 cell lysate with BRCC3 polyclonal antibody (Cat # PAB13012) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of BRCC3 in human brain tissue with BRCC3 polyclonal antibody (Cat # PAB13012) at 2.5 ug/mL . -
Gene Info — BRCC3
Entrez GeneID
79184Protein Accession#
NP_077308Gene Name
BRCC3
Gene Alias
BRCC36, C6.1A, CXorf53
Gene Description
BRCA1/BRCA2-containing complex, subunit 3
Omim ID
300617Gene Ontology
HyperlinkGene Summary
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
BRCA1/BRCA2-containing complex subunit 36|OTTHUMP00000061450|c6.1A
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Interactome
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Publication Reference
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BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation.
Chen X, Arciero CA, Wang C, Broccoli D, Godwin AK.
Cancer Research 2006 May; 66(10):5039.
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Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.
Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R.
Molecular Cell 2003 Nov; 12(5):1087.
Application：WB-Tr, Human, HEK 293 cells.
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BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation.
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