CBL polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CBL.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human CBL.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CBL in Daudi cell lysate with CBL polyclonal antibody (Cat # PAB12976) at (A) 0.5, (B) 1, and (C) 2 ug/mL .Immunofluorescence
Immunofluorescence of CBL in human lymph node tissue with CBL polyclonal antibody (Cat # PAB12976) at 20 ug/mL . -
Gene Info — CBL
Entrez GeneID
867Protein Accession#
P22681Gene Name
CBL
Gene Alias
C-CBL, CBL2, RNF55
Gene Description
Cas-Br-M (murine) ecotropic retroviral transforming sequence
Omim ID
165360Gene Ontology
HyperlinkGene Summary
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq
Other Designations
oncogene CBL2
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Interactome
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Pathway
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Disease
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Publication Reference
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The Cbl family proteins: ring leaders in regulation of cell signaling.
Swaminathan G, Tsygankov AY.
Journal of Cellular Physiology 2006 Oct; 209(1):21.
Application:WB, Human, Jurkat cells.
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c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.
Thien CB, Langdon WY.
The Biochemical Journal 2005 Oct; 391(Pt 2):153.
Application:WB-Tr, Human, Human mammalian cells.
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Themes and variations on ubiquitylation.
Weissman AM.
Nature Reviews. Molecular Cell Biology 2001 Mar; 2(3):169.
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The Cbl family proteins: ring leaders in regulation of cell signaling.
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